Distinguished by its svelte, rangefinder-inspired design, the FUJIFILM GFX 50R is a sleek medium format mirrorless camera that is notably portable and highly capable. Revolving around a 43.8 x 32.9mm 51.4MP CMOS sensor, which is paired with the X-Processor Pro image processor, the GFX 50R is capable of producing high-resolution still imagery with an extremely wide dynamic range, a broad sensitivity range up to an extended ISO 102400, and the sensor's large size contributes to a unique three-dimensional look with especially smooth tonal and color transitions. The sensor and processor also enable recording Full HD 1080p30 video.

Benefitting the imaging capabilities is a comfortable physical design, which incorporates a 3.69m-dot OLED electronic viewfinder for bright, clear eye-level viewing. Alternatively, the rear 3.2" 2.36m-dot touchscreen LCD features a three-way tilting design that supports working from high and low angles, even when shooting in the vertical orientation. Additionally, the GFX 50R has a durable magnesium-alloy build that is also dust- and weather-sealed, as well as freezeproof down to 14°F, for working in trying environmental conditions.